Morphine is one of the original opioids derived directly from the poppy plant, and its withdrawal follows a relatively classic opioid pattern.
Rough timeline: Onset within 8–12 hours of last use (longer for extended-release formulations), peak around 1–3 days, acute symptoms resolving by 5–7 days, with possible prolonged symptoms (PAWS) [link] for weeks after.
Common context: Morphine is frequently used in hospital settings for pain management; if withdrawal became a concern after hospital-administered morphine, that’s a conversation worth having directly with the treating team before discharge, not something to navigate alone afterward.
Moving to treatment: The same medication options apply as with other opioids — buprenorphine, methadone, or naltrexone. [MAT comparison tool]
Medically reviewed by [pending]. Source: SAMHSA TIP 63.