Withdrawal timing depends on the specific opioid, dosage, and duration of use. This is a general guide for short-acting opioids such as heroin and oxycodone.
During hours 36–72, focus entirely on hydration and rest. This is the hardest window.
After hour 72, remind yourself: it only gets better from here.
6–12
hours
Early Onset
The first signs appear 6–12 hours after the last dose. Anxiety, yawning, runny nose, irritability, and restlessness. The body begins signaling that it is not receiving opioids.
AnxietyYawningRunny noseIrritabilityRestlessness
Moderate
What to do: Begin hydrating now. Gather comfort supplies: blankets, heating pad, anti-diarrheal medication, ibuprofen.
12–36
hours
Symptoms Escalate
Muscle pain, chills, sweating begin. Sleep becomes very difficult. Nausea and stomach cramping start. This is when many people relapse — knowing this is coming helps you prepare.
Muscle achesChills and sweatingInsomniaNauseaGoosebumps
High
What to do: Take ibuprofen for aches. Use loperamide (Imodium) for diarrhea. Call a doctor if unmanageable — clonidine requires a prescription but provides significant relief.
36–72
hours
Peak Intensity — The Hardest Window
The most intense phase. Vomiting, diarrhea, severe muscle cramps peak here. Dehydration is a serious risk. Most relapses happen in this window — knowing it ends at ~72 hours is critically important.
Severe vomitingDiarrheaSevere crampsElevated heart rateRestless legs
Peak — Most severe window
Critical: Focus on hydration above all else. Small sips constantly. Electrolytes. Call 911 or go to ER if you cannot keep fluids down or have chest pain. This window ends.
Days 4–7
Acute Phase Resolves
Physical symptoms begin to clearly diminish. Appetite slowly returns. Vomiting and diarrhea resolve. Some muscle ache persists. Sleep may be possible for the first time. Mood may be low — this is normal and temporary.
Focus on: Light nutritious food. Gentle walking helps. Begin thinking about next steps: counseling, support groups, MAT evaluation.
Weeks 2–4
Post-Acute Withdrawal Syndrome (PAWS)
The acute phase is over but PAWS begins. The brain is still recalibrating its dopamine systems. Symptoms are psychological and intermittent — coming in waves, often triggered by stress. This is a high-relapse-risk period.
Mood swingsCravingsCognitive fogInsomniaAnxiety
Low–Moderate, intermittent
Support is critical: Professional counseling, peer support groups (NA, SMART Recovery), regular exercise, and daily routine dramatically improve PAWS outcomes.
Month 2+
Early Recovery — Brain Healing
The brain continues to heal. Dopamine systems gradually normalize. Most people in supported recovery notice significant improvement in mood, energy, sleep, and cognitive function between months 2–6. Cravings become less frequent and less intense.